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October is Awareness Month for Breast Cancer and These Other Health-Related Issues

October
1 - 31 Eye Injury Prevention Month American Academy of Ophthalmology P.O. Box 7424 San Francisco, CA 94120-7424 (415) 447-0213 (415) 561-8533 Faxeyemd@aao.org www.geteyesmart.org/eyesmart/injuries/in dex.cfm   Materials available Contact: Georgia Alward	1 - 31 Home Eye Safety Month Prevent Blindness America 211 West Wacker Drive, Suite 1700 Chicago, IL 60606 (800) 331-2020 (312) 363-6001 (312) 363-6052 Faxinfo@preventblindness.org www.preventblindness.org   Materials available Contact: PBA Consumer and Patient Hotline
1 - 31 National Breast Cancer Awareness Month National Breast Cancer Awareness Month Board of Sponsors C1C-315 1800 Concord Pike Wilmington, DE 19850-5437nbcamquestions@yahoo.com www.nbcam.org   Materials available Contact: None designated	1 - 31 National Disability Employment Awareness Month Office of Disability Employment Policy U.S. Department of Labor Frances Perkins Building, Room S-1303 200 Constitution Avenue NW Washington, DC 20210 (866) 633-7365 (202) 693-7880 (202) 693-7888 Fax (202) 693-7881 TTYwww.dol.gov/odep Materials available Contact: Carol Dunlap
1 - 31 National Down Syndrome Awareness Month National Down Syndrome Society 666 Broadway New York, NY 10012 (800) 221-4602 (212) 979-2873 Faxinfo@ndss.org www.ndss.org   Materials available Contact: Educational Services	1 - 31 National Medical Librarians Month Medical Library Association 65 East Wacker Place, Suite 1900 Chicago, IL 60601 (312) 419-9094 x11 (312) 419-8950 Faxmlams@mlahq.org www.mlanet.org/resources/nml-month/index .html   Materials available Contact: Tomi Gunn
1 - 31 National Physical Therapy Month American Physical Therapy Association 1111 North Fairfax Street Alexandria, VA 22314-1488 (800) 999-2782 (703) 684-2782 x3248 (703) 706-8578 Faxpublic-relations@apta.org www.moveforwardpt.com   Materials available Contact: Public Relations Department	1 - 31 Stop America's Violence Everywhere (SAVE) Today American Medical Association Alliance 515 North State Street, 9th Floor Chicago, IL 60654 (312) 464-4470 amaa@ama-assn.org www.amaalliance.org   Materials available Contact: None designated
1 - 31 Sudden Infant Death Syndrome Awareness Month First Candle/SIDS Alliance 1314 Bedford Avenue, Suite 210 Baltimore, MD 21208 (800) 221-7437 (410) 653-8226 (410) 653-8709 Faxinfo@firstcandle.org www.firstcandle.org   Materials available Contact: None designated	2 - 8 Mental Illness Awareness Week National Alliance on Mental Illness 3803 North Fairfax Drive, Suite 100 Arlington, VA 22203 (800) 950-6264 Helpline (703) 524-7600 (703) 524-9094 Faxinfo@nami.org www.nami.org   Materials available Contact: None designated
3 - 7 Drive Safely Work Week Network of Employers for Traffic Safety 344 Maple Avenue West, #357 Vienna, VA 22180 (888) 221-0045 (703) 273-6005 (703) 273-7122 Faxnets@trafficsafety.org www.trafficsafety.org   Materials available Contact: Liz Stevens	3 Child Health Day Maternal and Child Health Bureau Health Resources and Services Administration U.S. Department of Health and Human Services Parklawn Building, Room 1805 5600 Fishers Lane Rockville, MD 20857 (301) 443-2170 (301) 443-1797 Faxwww.mchb.hrsa.gov Contact: Cynthia Tibbs
5 Walk to School Day National Center for Safe Routes to School 730 Martin Luther King, Jr. Blvd, Suite 300 / Campus Box 3430 Chapel Hill, NC 27599-3430 866-610-SRTS (610-7787)walk@walktoschool.org  www.walktoschool-usa.org/index.cfm   Materials available Contact: Susan Byszeski	6 National Depression Screening Day ® Screening for Mental Health, Inc. One Washington Street, Suite 304 Wellesley Hills, MA 02481 (781) 239-0071 (781) 431-7447 Faxsmhinfo@mentalhealthscreening.org  www.mentalhealthscreening.org/events/nat ional-depression-screening-day.aspx   Materials available Contact: None designated
10 World Mental Health Day World Federation for Mental Health 12940 Harbor Drive, Suite 101 Woodbridge, VA 22192-2930 (703) 494-6515 (703) 494-6518 Faxwmhday@wfmh.com www.wfmh.org/00worldmentalhealthday.htm   Materials available Contact: Deborah Maguire	12 - 20 Bone and Joint Decade National Action Week U.S. Bone and Joint Decade 6300 North River Road Rosemont, IL 60018 (847) 384-4010 (847) 384-4009 (847) 823-1822 Faxusbjd@usbjd.org www.usbjd.org   Materials available Contact: Toby King
15 National Latino AIDS Awareness Day Latino Commission on AIDS 24 W 25th Street, 9th Floor New York, NY 10010 (212) 584-9315 (212) 202-3620 Faxmramirez@latinoaids.org www.nlaad.org/   Materials available Contact: Melissa Faith Ramirez	16 World Food Day U.S. National Committee for World Food Day 2175 K Street NW, Suite 500 Washington, DC 20437 (202) 653-2404 (202) 653-5760 Faxwww.worldfooddayusa.org   Materials available Contact: None designated
22 International Stuttering Awareness Day Stuttering Foundation of America 1805 Moriah Woods Boulevard, #3 P.O. Box 11749 Memphis, TN 38111-0749 (800) 992-9392 (800) 967-7700 (901) 761-0484 Faxinfo@stutteringhelp.org www.stutteringhelp.org   Materials available Contact: Jane Fraser	23 - 31 Red Ribbon Week National Family Partnership at Informed Families Education Center 2409 Coral Way, Suite 501 Miami, FL 33145 (800) 705-8997 (305) 856-4886 (305) 856-4815 Faxireyes@informedfamilies.org www.nfp.org   Materials available Contact: Ileana Reyes
31 - November 6 National Drug Facts Week National Institute on Drug Abuse National Institutes of Health 6001 Executive Boulevard, Room 5213 Bethesda, MD 20892-9561 (301) 443-1124 drugfacts@nida.nih.gov www.drugfactsweek.drugabuse.gov/ Materials available Contact: None designated

August is Awareness Month for...

August http://www.healthfinder.gov/nho/nho.asp#m8
1 - 31 Children's Eye Health and Safety Month Prevent Blindness America 211 West Wacker Drive, Suite 1700 Chicago, IL 60606 (800) 331-2020 (312) 363-6001 (312) 363-6052 Faxinfo@preventblindness.org www.preventblindness.org   Materials available Contact: PBA Consumer and Patient Hotline	1 - 31 National Immunization Awareness Month National Center for Immunization and Respiratory Diseases Centers for Disease Control and Prevention 1600 Clifton Road NE, MS E-05 Atlanta, GA 30333 (800) CDC-INFO (232-4636) English/Spanish (888) 232-6348 (TTY) (404) 639-7394 Fax (877) 394-8747 International Travel Informationwww.cdc.gov/vaccines/events/niam/default .htm Materials available Contact: None designated
1 - 7 World Breastfeeding Week World Alliance for Breastfeeding Action P. O. Box 4097 Schaumburg, IL 60168-4079 (847) 519-7730 (847) 969-0460 Faxwaba@waba.org www.worldbreastfeedingweek.org    Materials available Contact: None designated

Createability Team Annual Thanksgiving Sale

The team will have another annual sale over the US Thanksgiving weekend, from Thursday to Monday, November 25 to 29th.

Teammates are welcome to offer any sort of deal or sale they wish – a percentage off (some or all items), free shipping, BOGO, free gift, etc. You are also welcome to combine this sale with one from another team, or to offer it for a longer period of time.

We will again ask members to promote the sale however they can – blogs, twitter, Facebook, etc. We will run a promo thread again, & if Etsy runs any promotions for that weekend, we will submit teammates to be considered. Last year we got two teammates into the Etsy Finds email one day & both had several sales!


Here is a list of those team members participating in this year's event:
AilorsAttic.etsy.com 20% off everything
ajbcreations.etsy.com 40% off plus free gift
AStonesThrow.etsy.com Buy one, get one 50% off
beadedrelics.etsy.com 10% off everything
berrybluecreations.etsy.com 50% off select items
BirdhouseBlessings.etsy.com free marshmallowman ornament with $15 purchase
BlackMagicStudio.etsy.com Free shipping +10% off everything.
blacksheepdesigns.etsy.com 15% off everything
cabbingrough.etsy.com 50% off everything
Carapace.etsy.com prints for $7
cindylouwho2.etsy.com 10% off everything
crochetbymsa.etsy.com free shipping plus free gift
cuddlebugkids.etsy.com 10% off everything
Debsparkles.etsy.com 50% off select items
ElainaLouiseStudios.etsy.com 10% off + free shipping to US & Canada
EllesBelle.etsy.com 15% off everything
flamingolady.etsy.com Different sales through the shop
freshpikd4u.etsy.com 15% off everything use code HAPPYHOLIDAYS
GrannysKnits.etsy.com 50% off everything
HandPaintedPetals.etsy.com 10-20% off everything
Harvestmoonbyhand.etsy.com Free gift for every $10 spent (excluding shipping)
jeanetteranney.etsy.com Free shipping plus free gift
kittyanydots.etsy.com 20% off everything
MadeByMari.etsy.com Free Beaded Snowflake with any Purchase
May7th.etsy.com 25% off everything
merigreenleaf.etsy.com 15% off everything, excluding custom dolls.

mistyridge.etsy.com 10% off everything.
obachansflowers.etsy.com free shipping
PhotosByChipperfield.etsy.com BOGO sale, free shipping to US & Canada
RivetingArt.etsy.com 25% off everything; 40% off Black Friday only
Sunnyplainquilting.etsy.com 20% off everything
sunshinebycindy.etsy.com 10% off everything
For updates on the list of shops who are participating and for Createability members to get added to the list, please check out these Etsy Forum Threads:
http://www.etsy.com/teams/5732/createability-team/discuss/6676013/
http://www.etsy.com/forums_thread.php?thread_id=6670266

Interested in joining the Createability Team?
Here are the requirements: http://www.etsy.com/teams/5732/createability-team

Mitochondrial Disease Awareness Week

Some of the members of The Createability Team are already aware of Mitochondrial Disease. If you are not aware of this disease, you can find out more information by clicking on this link

http://www.umdf.org/site/c.otJVJ7MMIqE/b.5472191/k.BDB0/Home.htm

What is Mitochondrial Disease

Mitochondrial diseases result from failures of the mitochondria, specialized compartments present in every cell of the body except red blood cells. Mitochondria are responsible for creating more than 90% of the energy needed by the body to sustain life and support growth. When they fail, less and less energy is generated within the cell. Cell injury and even cell death follow. If this process is repeated throughout the body, whole systems begin to fail, and the life of the person in whom this is happening is severely compromised. The disease primarily affects children, but adult onset is becoming more and more common.

Diseases of the mitochondria appear to cause the most damage to cells of the brain, heart, liver, skeletal muscles, kidney and the endocrine and respiratory systems.

Depending on which cells are affected, symptoms may include loss of motor control, muscle weakness and pain, gastro-intestinal disorders and swallowing difficulties, poor growth, cardiac disease, liver disease, diabetes, respiratory complications, seizures, visual/hearing problems, lactic acidosis, developmental delays and susceptibility to infection.

Energy Factories and Much More

The conventional teaching in biology and medicine is that mitochondria function only as "energy factories" for the cell.  This over-simplification is a mistake which has slowed our progress toward understanding the biology underlying mitochondrial disease.  It takes about 3000 genes to make a mitochondrion.  Mitochondrial DNA encodes just 37 of these genes; the remaining genes are encoded in the cell nucleus and the resultant proteins are transported to the mitochondria.  Only about 3% of the genes necessary to make a mitochondrion (100 of the 3000) are allocated for making ATP.  More than 95% (2900 of 3000) are involved with other functions tied to the specialized duties of the differentiated cell in which it resides.  These duties change as we develop from embryo to adult, and our tissues grow, mature, and adapt to the postnatal environment.  These other, non-ATP-related functions are intimately involved with most of the major metabolic pathways used by a cell to build, break down, and recycle its molecular building blocks.  Cells cannot even make the RNA and DNA they need to grow and function with out mitochondria.  The building blocks of RNA and DNA are purines and pyrimidines.  Mitochondria contain the rate-limiting enzymes for pyrimidine biosynthesis (dihydroorotate dehydrogenase) and home synthesis (d-amino levulinic acid synthetase) required to make hemoglobin.  In the liver, mitochondria are specialized to detoxify ammonia in the urea cycle.  Mitochondria are also required for cholesterol metabolism, for estrogen and testosterone synthesis, for neurotransmitter metabolism, and for free radical production and detoxification.  They do all this in addition to breaking down (oxidizing) the fat, protein, and carbohydrates we eat and drink.

Defining Mitochondrial Disease

Mitochondrial diseases are the result of either inherited or spontaneous mutations in mtDNA or nDNA which lead to altered functions of the proteins or RNA molecules that normally reside in mitochondria.  Problems with mitochondrial function, however, may only affect certain tissues as a result of factors occurring during development and growth that we do not yet understand.  Even when tissue-specific isoforms of mitochondrial proteins are considered, it is difficult to explain the variable patterns of affected organ systems in the mitochondrial disease syndromes seen clinically.

Genocopies of Mitochondrial Disease

Because mitochondria perform so many different functions in different tissues, there are literally hundreds of different mitochondrial diseases.  Each disorder produces a spectrum of abnormalities that can be confusing to both patients and physicians in early stages of diagnosis.  Because of the complex interplay between the hundreds of genes and cells that must cooperate to keep our metabolic machinery running smoothly, it is a hallmark of mitochondrial diseases that identical mtDNA mutations may not produce identical diseases.  Genocopies are diseases that are caused by the same mutation but which may not look the same clinically.

Phenocopies of Mitochondrial Disease

The converse is also true: different mutations in mtDNA and nDNA can lead to the same diseases.  In genetics, these are known as phenocopies.  A good example is Leigh syndrome, which can be caused by about a dozen different gene defects.  Leigh syndrome, originally a neuropathological description of the brain of one affected child, was described by Denis Leigh, the distinguished British physician, in 1951.  It is characterized by bilaterally symmetrical MRI abnormalities in the brain stem, cerebellum, and basal ganglia, and often accompanied by elevated lactic acid levels in the blood or cerebrospinal fluid.  Leigh syndrome may be caused by the NARP mutation, the MERRF mutation, complex I deficiency, cytochrome oxidase (COX) deficiency, pyruvate dehydrogenase (PDH) deficiency, and other unmapped DNA changes.  Not all children with these DNA abnormalities will go on to develop Leigh syndrome, however.

Mitochondrial diseases are even more complex in adults because detectable changes in mtDNA occur as we age and, conversely, the aging process itself may result from deteriorating mitochondrial function.  There is a broad spectrum of metabolic, inherited and acquired disorders in adults in which abnormal mitochondrial function has been postulated or demonstrated.

Adapted/selected sections from Robert Naviaux's "Overview, the Spectrum of Mitochondrial Disease" in the Mitochondrial and Metabolic Disorders, Primary Care Physician's Guide, second edition.